$41.820.07
48.790.18

AI-powered Parkinson's disease treatment: Scientists propose an updated method

Kyiv • UNN

 • 11334 views

Adaptive deep brain stimulation using AI significantly reduced motor symptoms of Parkinson's disease. The new method personalizes therapy based on the patient's brain activity in real time.

AI-powered Parkinson's disease treatment: Scientists propose an updated method

Adaptive deep brain stimulation has virtually eliminated the most debilitating motor symptoms in some patients with Parkinson's disease. This has given scientists hope that the new method will be able to help many other patients with this disease.

This is reported by UNN with a reference to WashingtonPost.

Features of Parkinson's disease

Like the heart, the brain has normal rhythms of electrical activity produced by neurons. Diseases such as epilepsy and schizophrenia are associated with abnormal brain rhythms, similar to cardiac arrhythmias. And in Parkinson's disease, neurons in the brain become too synchronized in so-called oscillopathy. This can interfere with normal information transmission and lead to symptoms such as tremors and stiffness.

Imagine you are in a crowd and there is a buzz of conversation, but you can easily hear your conversation - this is a normal situation of broadband neural activity. But with oscillopathy, it's like a protest march where everyone is chanting the same thing, and you can't hear yourself talking

- explained Helen Bronte-Stewart, professor of neurology and neurological sciences at Stanford School of Medicine. 

Dementia can be prevented: lowering bad cholesterol levels can significantly reduce the risk of developing the disease02.04.25, 16:36 • 16166 views

Methods of combating the disease

Deep brain stimulation (DBS) is a surgical therapy for treating the symptoms of Parkinson's disease. A device similar to a pacemaker is implanted in the brain to deliver electrical impulses. This method of treatment has been used since 1997.

Adaptive brain stimulation method

According to experts, DBS and Parkinson's disease medications weaken oscillopathy in the brain. In particular, constant electrical impulses from DBS help stimulate neuron activation, returning brain rhythms to normal.

Early detection of Parkinson's disease: a new test will help you avoid waiting for symptoms for years21.03.24, 14:39 • 24713 views

Conventional DBS provides electrical stimulation at a constant setting. This can lead to periods of under- and overstimulation, which in turn leads to slowing of movements or dyskinesia, respectively.

The updated, adaptive brain stimulation method personalizes therapy based on the patient's brain activity in real time using AI.

In February, the Food and Drug Administration approved the first adaptive DBS system for people with Parkinson's disease.

For some patients, especially those with more severe symptoms, standard DBS, which is always on in one constant mode, does not provide enough benefit. The brain's needs change depending on their activity level, such as when they are awake or asleep, and especially according to the medication cycle

- noted Philip Starr, professor of neurological surgery at the University of California, San Francisco.

Hypotension: what it is and why it is dangerous21.10.24, 12:19 • 14849 views

Research

Previous studies have shown that adaptive DBS improves motor control, has fewer side effects, and delivers less electrical energy compared to conventional DBS.

In 2024, Starr and his colleagues conducted a pilot study involving four patients with Parkinson's disease. It found that adaptive DBS improved motor symptoms and quality of life compared to conventional DBS.

The researchers personalized the algorithms for each patient, bringing them into the clinic and measuring their brain rhythms while taking or excluding levodopa, a Parkinson's drug used to increase dopamine levels.

One way to develop these kinds of algorithms is to first conduct some research on brain signals in known conditions. Then you can train an artificial intelligence algorithm on this known data so that the AI program learns which combination of brain signals is associated with different states

- explained Starr.

Parkinson's disease will affect more than 25 million people by 2050 - research19.03.25, 21:39 • 22199 views

Clinical trial

The ADAPT-PD clinical trial included 68 patients with Parkinson's disease who had previously been implanted with a conventional DBS system. They were fitted with adaptive DBS and the participants were sent home for 30 days.

Although the full results of the study have not yet been published, preliminary data revealed no serious side effects, and 98% of participants chose to remain on adaptive DBS during long-term follow-up.

Risks and contraindications

Experts note that adaptive DBS or conventional DBS will not benefit every patient. Both motor and non-motor symptoms (postural instability, stiffness, gastrointestinal problems, and sleep problems) may still remain.

In addition, any surgery carries risk, and people with heart disease and high blood pressure are more likely to get an infection, stroke, brain hemorrhage, or complications related to anesthesia.

Not everyone with Parkinson's disease is a good candidate for any type of DBS. Patients should have a good response to dopaminergic drugs such as levodopa and should not be too advanced in their disease

- noted Bronte-Stewart.

Currently, scientists continue to improve adaptive deep brain stimulation, but hope that the new method will be able to help many other patients with Parkinson's disease.

For the first time, researchers have traced the formation of amyloids associated with Alzheimer's disease with unprecedented accuracy04.11.24, 12:22 • 19070 views

Tesla
$
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
.
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
S&P 500
$
0
0
1
2
3
4
5
6
7
8
9
,
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
Brent Oil
$
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
.
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
Gold
$
0
0
1
2
3
4
5
6
7
8
9
,
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
Gas TTF
$
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9
.
0
0
1
2
3
4
5
6
7
8
9
0
0
1
2
3
4
5
6
7
8
9