Thanks to its ability to regenerate, the axolotl salamander is a very popular animal in scientific research. New discoveries allow us to develop a line of revolutionary cosmeceutical products to protect, restore skin and fight aging.
Writes UNN with reference to Medscape.
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For more than 200 years, researchers have been fascinated by the Axolotl salamander (Ambystoma mexicanum) and its amazing regenerative abilities, seeking to uncover secrets that could revolutionize regenerative medicine.
Salamander axolotl can regenerate limbs, part of the heart, even the brain
After studying the axolotl over the past decade, scientists have noted the importance of gene activity in controlling skin regeneration. In particular, growth factors such as fibroblast growth factors, transforming growth factor beta, and Wnt play a key role in controlling the behavior of the skin cells during healing and regrowth.
It was found that the actions of macrophages and neutrophils are important in the early stages of regeneration, as these cells remove dead tissue and start the healing process.
Based on the new discovery, researchers are working on a line of cosmeceutical and over-the-counter products containing urodele collagen extract derived from neotenic animal tissue without harming it.
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The axolotl (Ambystoma mexicanum) is an aquatic salamander known for its ability to regenerate its spinal cord, heart, and limbs. These amphibians also easily produce new neurons throughout their lives.
In axolotls, the damaged neotenic tissue “thinks” it is in fetal mode, so if you damage its muscles, bones, nerves, collagen, or skin, everything will repair itself. Axolotl has scarless healing and immunity due to the antimicrobial properties contained in the neotenic tissue,” explains Jill S. Weibel, MD.
RegenX scientists have developed a patented decellularization process that makes Urodele collagen extract safe and effective for use in the human body.
We have used a reservoir of bioactive peptides, which are small proteins that originate from the axolotl, but they do not contain RNA or DNA that could cause a risk of any disease or cancer
It is also known that urodele collagen extract has anti-inflammatory and analgesic properties.
“It reduces TNF [tumor necrosis factor] and IL-23 and stimulates regenerative pathways such as FETUB (Fetuin-B), which is a gene involved in tissue regeneration,” says , MD.
Institutional Review Board-approved human clinical trials at three U.S. sites are nearly complete to evaluate the anti-aging moisturizing daily serum, anti-aging serum for damaged skin, and a regenerating serum for use after cosmetic procedures containing the extract.
The closest product is a “super-gel” that contains the properties of urodea collagen extract.
Looking ahead, the million-dollar question, Weibel said, is how much healing can be achieved in humans with the technology's axolotl-derived formulations.
For example, can we help a patient with a spinal cord injury? It sounds like a science fiction movie, but there are proteins in the genes of this animal that we have turned off that can potentially be turned on in the human body. It's very exciting.
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